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According to the Mayo Clinic, parenteral vitamin B12 therapy is clinically indicated for treating deficiency caused by pernicious anemia, gastrointestinal disorders such as tropical sprue, and conditions resulting in malabsorption like pancreatic insufficiency

hydroxocobalamin circulates in the body for a much longer time, because it binds loosely to proteins in the blood

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Although there is no single universal recommendation, health organizations generally recommend sufficient amounts to meet nutritional needs and maintain good health